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  • Title: [The effect of catecholamine and serotonin antibodies on pain sensitivity and the development of morphine tolerance in experimental drug addiction].
    Author: Vetrilé LA, Basharova LA, Igon'kina SI, Trekova NA, Evseev VA.
    Journal: Biull Eksp Biol Med; 1993 Nov; 116(11):453-5. PubMed ID: 8312524.
    Abstract:
    The effect of antibodies to catecholamine and serotonin on the thermal pain sensitivity and tolerance to morphine was studied in rats immunized by protein-conjugated neurotransmitters before chronic drug intoxication. The antibodies to catecholamine have been found to affect bifunctionally on the nociception bifunctionally: either accelerating or delaying the pain reaction to thermal irritation. The antibodies to serotonin were ineffective as modulators both of the pain sensitivity and tolerance to morphine development. In contrast, the antibodies to catecholamine suppressed the expression of tolerance to chronic morphine. Serotonin antibodies virtually produced no effects on pain sensitivity and the development of morphine tolerance.
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