These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Changes in the level of cyclic nucleotides in the left and right sensorimotor areas of the cerebral cortex in rats after corazol-induced kindling].
    Author: Glebov RN, Karpova MN, Goriacheva TV, Mikhal'skaia IO, Spasskaia ME, Pankov OIu.
    Journal: Biull Eksp Biol Med; 1993 Nov; 116(11):491-3. PubMed ID: 8312537.
    Abstract:
    Levels of cAMP and cGMP in the left and right areas of the rat sensorimotor cortex (SMC) 7 days after pentylenetetrazole kindling (30 days) were determined by radioimmunological assay. It is shown that levels of cyclic nucleotides remained unchanged in rats SMC 7 days after single injection of seizure dose (70 mg/kg) of pentylenetetrazole. Levels of cAMP and cGMP in SMC increased by 2-3 times after 30-day administration of physiological saline as compared to single injection; cortical asymmetry of cAMP and cGMP is absent. Differences in the levels of cyclic nucleotides in sensitive and low-sensitive animals to pentylenetetrazole were not revealed. When kindling was completed cGMP level increased in right SMC and it decreased in left SMC as compared to control animals; cAMP level was unaltered in left and increased in right SMC. The role of cortical asymmetry of cyclic nucleotides development of seizure state is discussed.
    [Abstract] [Full Text] [Related] [New Search]