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  • Title: [The effect of 3-mercaptopropionic acid on the toxicity of GABA-lytics for mice].
    Author: Golovko AI, Sofronov GA, Kliuntina TV.
    Journal: Biull Eksp Biol Med; 1993 Nov; 116(11):526-7. PubMed ID: 8312550.
    Abstract:
    The influence of 3-mercaptopropionic acid (3-MPA) on toxicities of bicuculline and picrotoxin was evaluated in mice. It was demonstrated that 3-MPA pretreatment for 5 min increased the toxicities of bicuculline and picrotoxin by 26% and 31%, respectively. 3-MPA did not alter the binding of (3H)TBOB and (3H)GABA to synaptosomal brain membranes of intact mice. The changes in toxicity may be associated with increased binding of GABA-antagonists to their receptors due to decreased brain GABA.
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