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  • Title: Linkage detection by the Affected-Pedigree-Member method: what is really tested?
    Author: Babron MC, Martinez M, Bonaïti-Pellié C, Clerget-Darpoux F.
    Journal: Genet Epidemiol; 1993; 10(6):389-94. PubMed ID: 8314032.
    Abstract:
    We show that the null hypothesis in the Affected-Pedigree-Member (APM) method is composed of two sub-hypotheses: no linkage and correct marker allele distribution. As a result, the APM method is not robust to misspecification of marker allele frequencies.
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