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  • Title: Acute renal failure after high-dose intravenous immune globulin in a patient with idiopathic thrombocytopenic purpura.
    Author: Ruggeri M, Castaman G, De Nardi G, Rodeghiero F.
    Journal: Haematologica; 1993; 78(5):338-9. PubMed ID: 8314166.
    Abstract:
    High-dose intravenous immunoglobulin (IVIG) is considered a safe and efficacious treatment for patients with a variety of hematological and non hematological diseases, including patients with idiopathic thrombocytopenic purpura (ITP) not responsive or with contraindications to corticosteroids and/or splenectomy. Side-effects are usually minor, but severe reactions have been rarely reported. We describe the case of a patient with ITP, without pre-existing renal disease, who developed a severe transitory acute renal failure following administration of IVIG, promptly reversed after hemodialysis.
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