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  • Title: Hemodynamic changes induced by cilazapril and atenolol during isometric stress in hypertensive patients.
    Author: Pancera P, Arosio E, Priante F, Ribul M, De Marchi S, Lechi A.
    Journal: Int J Clin Pharmacol Ther Toxicol; 1993 Dec; 31(12):582-7. PubMed ID: 8314358.
    Abstract:
    We studied 16 mild to moderate essential hypertensive patients (14 male, 2 female; mean age 45 years, range 34-55 years) in order to investigate the effects of an ACE inhibitor, cilazapril (5 mg o.d.) and a selective beta-blocker, atenolol (100 mg o.d.) on the hemodynamics of the brachial and carotid arteries after an isometric stress test with a handgrip. Both drugs caused a statistically significant decrease in blood pressure after three months' treatment, but only cilazapril reduced it after the first dose. Heart rate was reduced only by atenolol (61 +/- 3 vs 71 +/- 3 bpm; p < 0.01). Changes in forearm compliance and characteristic impedance showed a difference statistically significant both for acute test and after three months of treatment. The increase in blood pressure during handgrip did not differ appreciably between the two treatment groups. On the contrary, after handgrip only cilazapril caused a significant increase of the reactive hyperemia.
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