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  • Title: Clinical and histological evaluation of interferon alfa-2b in the treatment of chronic hepatitis C.
    Author: Panella C, Francavilla A, Conte D, Tatulli I, Rubini F.
    Journal: Gut; 1993; 34(2 Suppl):S127. PubMed ID: 8314478.
    Abstract:
    In a study of 37 patients with hepatitis C (proved histologically) positive chronic hepatitis, a correlation was seen between clinical efficacy and histological improvement after treatment with interferon alfa-2b (3 million units (MU) three times a week for six months plus six months' follow up). Alanine aminotransferase activities became normal in 18 (48%) patients during treatment; at the end of follow up eight (45%) had a continued response to the treatment. Paired liver biopsy specimens showed marked improvements in Knodell index score and portal inflammation in these patients.
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