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  • Title: Multiple system atrophy. Clinical and MR observations on 42 cases.
    Author: Testa D, Savoiardo M, Fetoni V, Strada L, Palazzini E, Bertulezzi G, Girotti F.
    Journal: Ital J Neurol Sci; 1993 Apr; 14(3):211-6. PubMed ID: 8314674.
    Abstract:
    Probable or possible multiple system atrophy (MSA) was diagnosed on strict clinical criteria in 42 patients: 20 with combined parkinsonism and cerebellar ataxia, 9 with striatonigral degeneration (SND) and 13 with olivopontocerebellar atrophy (OPCA). All patients were then studied with 0.5 and/or 1.5 Tesla magnetic resonance (MR) units. MR imaged putaminal abnormalities in all 9 patients with SND and posterior fossa abnormalities consistent with OPCA in all 13 patients with this diagnosis. Of the 20 patients with parkinsonism and cerebellar involvement, classified as probable MSA, 7 presented putaminal abnormalities only, 3 abnormalities consistent with OPCA only and 10 a combination of both. These findings show strong MRI support for the clinical diagnosis of MSA.
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