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  • Title: Improvement of cardiac performance by pimobendan, a new cardiotonic drug, in the experimental failing dog heart.
    Author: Satoh K, Satoh Y, Imagawa J, Taira N.
    Journal: Jpn Heart J; 1993 Mar; 34(2):213-9. PubMed ID: 8315818.
    Abstract:
    The cardiotonic effect of pimobendan was studied in 6 dog heart-lung preparations in which cardiac function had been severely depressed by pentobarbital. Pimobendan in doses of 1-10 mg improved cardiac function in a dose-dependent manner and at 10 mg improved it beyond the control. These doses of pimobendan, however, produced neither a significant increase in heart rate nor arrhythmias. The results indicate that the drug may be of use in the treatment of heart failure.
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