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  • Title: [Refractory acute myelogenous leukemia successfully treated with a continuous infusion chemotherapy of low dose aclarubicin and cytosine arabinoside: a case report].
    Author: Kawada H, Komatsuda M, Masumoto A, Fukuda R, Watanabe S, Yonekura S, Ichikawa Y, Nagao T, Arimori S.
    Journal: Rinsho Ketsueki; 1993 May; 34(5):667-9. PubMed ID: 8315839.
    Abstract:
    A 44-year-old female with refractory acute myelogeneous leukemia had experienced an early relapse after a third complete remission (CR) with combination chemotherapy (BHAC-AMP) using daily one-shot infusion of 20 mg aclarubicin (ACR). Further treatments including intermediate dose of cytosine arabinoside (Ara-C) were not effective. After treatment with a continuous administration of low dose ACR (9 mg/day) and Ara-C (21 mg/day) for 14 days she entered a fourth CR. The mechanism of this treatment relates to both cell-killing and differentiation effects on leukemic cells.
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