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  • Title: Effects of ethynyl estradiol on incorporation of (1-14C) oleate into triglyceride and ketone bodies by the liver.
    Author: Weinstein I, Soler-Argilaga C, Heimberg M.
    Journal: Biochem Pharmacol; 1977 Jan 01; 26(1):77-80. PubMed ID: 831729.
    Abstract:
    The effect of ethinyl estradiol (EE) on the incorporation of (1-carbon-14) oleate into triglyceride and ketone bodies by the rat liver was investigated. Treatment with EE resulted in significant increases in the incorporation of oleate into hepatic (p less than .05) and perfusate (p less than .005) triglycerides. However, the incorporation of oleate into ketone body perfusate was significantly (p less than .001) reduced, though liver incorporation was not markedly affected. Liver uptake of fatty acid was somewhat lower in treated rats. Possible mechanisms for the increased rate of secretion of triglycerides following treatment with EE are briefly discussed.
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