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  • Title: [Inactivation of prostaglandin H synthase from sheep vesicular glands with acetylenic fatty acids].
    Author: Sheve Kh, Belosludtsev IuIu, Demin PM, Khol'tskhiutter KhG, Sheve T, Miakova GI, Evstigneeva RP.
    Journal: Bioorg Khim; 1993 May; 19(5):548-54. PubMed ID: 8318023.
    Abstract:
    Acetylenic fatty acids, 8,11,14-eicosatrienoic, 5,8,11,14-eicosatetraenoic and 5,8,11,14,17-eicosapentaenoic acids, were compared with respect to their effects on the particulate prostaglandin H synthase. All the acetylenic acids inactivated the enzyme in a time-dependent manner. The eicosatriynoic and eicosatetraynoic acids exhibited comparable efficacies, whereas the eicosapentaenoic acid proved to be a weaker inactivator. The time-courses of inactivation fitted a kinetic model suggest an enzyme-catalysed conversion of the compounds via alternative suicidal and non-suicidal routes. The characteristics of inactivation of prostaglandin H synthase differ from those of lipoxygenases.
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