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  • Title: Locomotor and exploratory activity in three inbred strains of mice from young adulthood to senescence.
    Author: Lhotellier L, Perez-Diaz F, Cohen-Salmon C.
    Journal: Exp Aging Res; 1993; 19(2):177-87. PubMed ID: 8319735.
    Abstract:
    Nine variables measuring activity and exploratory behavior were collected for nine independent groups of three inbred strains of mice (BALB/c, C57BL/6, and DBA/2) at three ages (150, 400, and 750 days). An analysis of variance measuring differences of performances and a covariance analysis estimating the evolution of scores with age shows that (1) some variables are unaffected by age; (2) a strain-age interaction is observed for some variables; (3) some groups do not exhibit any age-related change for certain variables; and (4) the level of ability of age-related behavior varies across groups. These data argue for rejection of a general factor of aging and suggest that we are dealing with two distinct phenotypes: performance, and age-related modification of the performance, which therefore are not linked.
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