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  • Title: Ontogeny of calcitonin gene-related peptide immunoreactivity in rat lumbar motoneurons: delayed appearance and sexual dimorphism in the spinal nucleus of the bulbocavernosus.
    Author: Forger NG, Hodges LL, Breedlove SM.
    Journal: J Comp Neurol; 1993 Apr 22; 330(4):514-20. PubMed ID: 8320341.
    Abstract:
    Immunoreactivity for calcitonin gene-related peptide (CGRP) has been observed in both adult and embryonic rat motoneurons. However, the developmental pattern of CGRP expression in motoneurons has not been systematically examined and the role of CGRP in neuromuscular development is poorly understood. We have mapped the ontogeny of CGRP-like immunoreactivity in three motoneuron pools of the rat lumbar spinal cord from birth through adulthood. Immunoreactivity was uniformly high in lateral horn motoneurons (the retrodorsolateral nucleus) of males and females at all ages examined. The majority of motoneurons of the dorsolateral nucleus also were positive throughout postnatal development although the percentage of positive motoneurons was slightly higher in males than in females. In contrast, virtually no motoneurons of the spinal nucleus of the bulbocavernosus, located in the medial ventral horn, were positive for CGRP in neonatal rats. CGRP-like immunoreactivity was delayed in this nucleus until approximately postnatal day 6 in males and day 27 in females. Because these three motoneuronal nuclei are differentially sensitive to early androgen and differ with respect to the timing of several developmental milestones, these observations have implications for the regulation and possible roles of CGRP in developing motor systems.
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