These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Sequence homology of NADH CoQ reductase subunit IV with nucleotide-requiring enzymes.
    Author: Isashiki Y, Ohba N, Uto M, Nakagawa M.
    Journal: Jpn J Ophthalmol; 1993; 37(1):39-42. PubMed ID: 8320863.
    Abstract:
    The amino acid sequence of NADH CoQ reductase subunit IV is highly homologous with those of enzymes such as ATPase, argininosuccinate synthetase and adenylate kinase. Replacement of arginine by histidine in three enzymes was shown to result in loss of enzyme activity, causing pathologies including citrullinemia. As an analogy, we submit the hypothesis that replacement of arginine by histidine in NADH CoQ reductase subunit IV leads to its activity change, and ultimately results in Leber's hereditary optic neuropathy.
    [Abstract] [Full Text] [Related] [New Search]