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  • Title: The cytosolic acidification in rat parotid cells is associated with an increase in cytosolic Ca2+ concentration.
    Author: Tanimura A, Tojyo Y, Matsumoto Y.
    Journal: Jpn J Pharmacol; 1993 Apr; 61(4):357-60. PubMed ID: 8320881.
    Abstract:
    A transient decrease in cytosolic pH ([pH]i) in rat parotid cells was evoked by the addition of carbachol (CCh), phenylephrine, or substance P, whereas isoproterenol and dibutyryl cyclic AMP had little or no effect on [pH]i. The decrease in [pH]i induced by the Ca(2+)-mobilizing agonists was also observed in Ca(2+)-free medium, but not when the intracellular Ca2+ stores were previously depleted. Ionomycin and thapsigargin elicited a decrease in [pH]i with an increase in cytosolic Ca2+ concentration ([Ca2+]i). The protein kinase C activator and inhibitor had no effect on the agonist-induced decrease in [pH]i. These results suggest that the cytosolic acidification is associated with an increase in [Ca2+]i.
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