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  • Title: [The quantitative assay of (1-->3)-beta-D-glucan in culture medium of Candida albicans using G-test].
    Author: Kato H, Nakao A, Kambe T, Tanaka K, Tamura H, Tanaka S, Takagi H.
    Journal: Nihon Geka Gakkai Zasshi; 1993 Apr; 94(4):329-33. PubMed ID: 8321180.
    Abstract:
    It has been difficult to diagnose the deep-seated fungal infection. Limulus test which originally has been developed to detect endotoxin in blood is also activated by (1-->3)-beta-D-glucan, the cell wall component of the fungi. Factor G in limulus lysate is activated by (1-->3)-beta-D-glucan and not by endotoxin. The quantitative assay of (1-->3)-beta-D-glucan is possible by the G-test using factor G. (1-->3)-beta-D-glucan in RPMI culture medium of Candida albicans was periodically measured using G-test and the effect of antifungal drug or neutrophil to the changes of (1-->3)-beta-D-glucan in the culture medium was studied. Increase in the level of (1-->3)-beta-D-glucan was in parallel with the growth of Candida albicans. G-test may be applied to the clinical diagnosis of fungal infection.
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