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  • Title: Heterogeneity of mast cells at multiple body sites. Fluorescent determination of avidin binding and immunofluorescent determination of chymase, tryptase, and carboxypeptidase content.
    Author: Weidner N, Austen KF.
    Journal: Pathol Res Pract; 1993 Mar; 189(2):156-62. PubMed ID: 8321743.
    Abstract:
    Human mast cells (MCs) from multiple sites were studied to determine heterogeneity of expression of chymase, tryptase, and/or carboxypeptidase and the binding to avidin. Three immunophenotypes were found: MCs positive for tryptase (MCT), no immunodetectable chymase; MCs positive for tryptase and chymase (MCTC); and MCs positive for chymase (MCC), no immunodetectable tryptase. Chymase-positive MCs also bound avidin and contained carboxypeptidase. In breast skin and parenchyma and axillary lymph nodes > 95% were MCTC; a rare MC in skin and lymph nodes was MCT or MCC. In lung alveoli 91% of MCs were MCT, 8% were MCTC and 1% MCC. In bowel mucosa 58% of MCs were MCT, 35% were MCTC and 7% MCC, whereas in bowel submucosa 83% of MCs were MCTC and 17% MCC. Within esophageal epithelium 38% were MCT and 62% MCTC; whereas, in esophageal subepithelium all were MCTC. This study further documents site-dependent diversity among normal human MCs and recognizes a novel third immunophenotype rich in chymase and relatively deficient in tryptase, the MCC cell.
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