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  • Title: [Efficacy of 2 different leukocyte filters for erythrocyte concentrates].
    Author: Barth A, Passerini M, Oppliger R, Spycher M, Nydegger U.
    Journal: Schweiz Med Wochenschr; 1993 Jun 05; 123(22):1160-4. PubMed ID: 8322051.
    Abstract:
    By leukocyte reduction in red blood cell concentrates to < 5 x 10(6) leukocytes per transfused unit, febrile non-hemolytic transfusion reaction as well as alloimmunization and transmission of certain viral diseases (CMV, HTLV-1) can be prevented. Using a Nageotte hemocytometer with a large-volume chamber, the residual leukocyte number after filtration of 40 buffy-coat free red blood cell units with the filters Pall RC100 and Sepacell R500 B1 was determined in a clinical routine setting. Both tested filters underscored the limit (< 5 x 10(6) leukocytes per unit) set by the American Association of Blood Banks. Hemoglobin loss accounted for 8.9 g (Pall RC100) versus 7.7 g (Sepacell R500 B1), which is about 15-18% of the hemoglobin content of a red blood cell concentrate.
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