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  • Title: [Disorders of the liberation of tissue-type plasminogen activator (t-PA) from the venous wall as a cause for recurrent thromboses].
    Author: Hach-Wunderle V, Scharrer I.
    Journal: Vasa Suppl; 1993; 39():5-10. PubMed ID: 8322122.
    Abstract:
    The release of tissue-type plasminogen activator (t-PA) after venous occlusion was tested in 290 patients with venous thrombosis, at earliest three months after the last thrombo-embolic episode. In 37 patients (12.8%) the t-PA-activity was decreased. In 14 patients (4.8%) the defect was confirmed by control. A reduced release of t-PA was found in 4 patients, while 10 out of 14 patients had comparatively higher levels of plasminogen-activator-inhibitor (PAI-I).
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