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  • Title: Protection of germ-free mice from infection by Helicobacter felis after active oral or passive IgA immunization.
    Author: Czinn SJ, Cai A, Nedrud JG.
    Journal: Vaccine; 1993; 11(6):637-42. PubMed ID: 8322486.
    Abstract:
    Helicobacter pylori infection of human gastric epithelium has been associated with gastritis, ulcers and gastric cancers. In an H. felis, germ-free mouse model of infection, oral immunization with bacterial antigens plus cholera toxin resulted in elevated serum, gastric and intestinal anti-H. felis antibody titres and protection from acute infection. Mice given monoclonal IgA anti-H. felis antibody at the time of initial challenge were also protected from infection. These results demonstrate that oral vaccination may be a feasible approach for the prevention of H. pylori infection of humans.
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