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  • Title: [Immunoglobulin deposition in skeletal muscle in polymyositis and dermatomyositis].
    Author: Chen L, Guo Y.
    Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 1993 Feb; 15(1):55-7. PubMed ID: 8324838.
    Abstract:
    An immunohistochemical study was conducted using the biotin avidin technique in 22 muscle specimens from PM/DM patients and 19 control subjects. Deposition of IgG, IgM or C3 in the wall of capillaries and small vessels was demonstrated in 72.7% of PM/DM patients and in 31.6% of those with other neuromuscular disorders. This finding supports the contention that immunoglobulins and complement-mediated immunoreaction may play an important role in PM/DM pathogenesis.
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