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  • Title: Cotranslational heme binding to nascent globin chains.
    Author: Komar AA, Kommer A, Krasheninnikov IA, Spirin AS.
    Journal: FEBS Lett; 1993 Jul 12; 326(1-3):261-3. PubMed ID: 8325375.
    Abstract:
    Globin synthesis in cell-free extracts of rabbit reticulocytes was carried out in the presence of 3H-labeled hemin. Sucrose gradient centrifugation analysis revealed [3H]hemin in the polyribosome fraction. The addition of puromycin resulted in the release of both [3H]hemin- and [14C]leucine-labeled polypeptide from the polyribosomes. The data suggest cotranslational folding of the globin molecule on the ribosome and cotranslational heme binding to the nascent globin chain.
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