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  • Title: [The importance of body weight in treatment with digoxin and digoxin derivatives (author's transl)].
    Author: Schneider J, Ruiz-Torres A.
    Journal: Dtsch Med Wochenschr; 1977 Jan 28; 102(4):116-8. PubMed ID: 832590.
    Abstract:
    A total of 1109 determinations of digoxin concentration in serum were performed in 317 patients with cardiac failure during oral maintenance therapy with digoxin, beta-acetyldigoxin and beta-methyldigoxin. It was shown that the optimal therapeutic serum concentration (1.21 to 1.70 ng/ml) can be obtained reliably if the dosage of digoxin and its derivatives is based on the body weight. The daily doses recommended for oral maintenance therapy are 4mug/kg for beta-methyldigoxin, 5 mug/kg for beta-acetyldigoxin, and 8 mug/kg for digoxin. For initiating cardiac therapy the double maintenance dose can be prescribed once. Digoxin derivatives should be preferred to digoxin when choosing the drug.
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