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  • Title: [Premature cutaneous porphyria caused by oral contraceptives (author's transl)].
    Author: Leonhardi G, Schneider C, Gürenci J.
    Journal: Dtsch Med Wochenschr; 1977 Feb 04; 102(5):160-2. PubMed ID: 832602.
    Abstract:
    Four women, aged 23 to 26 years, fell ill with cutaneous hepatic porphyria. All of them had taken oestrogen-contaning oral contraceptives three to eight years before the illness. In one instance there was a time relationship with a progestogen preparation. The clinical and biochemical signs were those of porphyria cutanea tarda, but contrary to this disease there was a shift towards heptacarboxyporphyrin in the uroporphyrin/heptacarboxyporphyrin ratio (thin-layer chromatography, classified according to Doss). This difference and the onset at an early age suggest that the described disease may be called a hormone-induced premature cutaneous porphyria.
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