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  • Title: Effect of clonidine and chlorpromazine on centrally evoked electrodermal responses and their interaction with yohimbine.
    Author: Koss MC.
    Journal: Eur J Pharmacol; 1977 Jan 21; 41(2):221-4. PubMed ID: 832676.
    Abstract:
    Both clonidine and chlorpromazine reduced the amplitude of electrodermal responses (EDR) evoked by stimulation of the hypothalamus at a constant submaximal frequency (10-16 Hz). The ED50 for clonidine was approximately 5 mug/kg and that for chlorpromazine was about 1 mg/kg. Yohimbine pretreatment (0.5 mg/kg, i.v.) antagonized the effects of clonidine but did not alter the effectiveness of clorpromazine in inhibiting these responses. Yohimbine alone was without effect on these sympathetic-cholinergic responses. These results suggest that clonidine and chlorpromazine deress central sympathetic reactivity by different mechanisms.
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