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  • Title: Microinjections of flupenthixol into the caudate putamen of rats produce intrasession declines in food-rewarded operant responding.
    Author: Beninger RJ, D'Amico CM, Ranaldi R.
    Journal: Pharmacol Biochem Behav; 1993 Jun; 45(2):343-50. PubMed ID: 8327540.
    Abstract:
    Results of recent studies suggest that dopamine (DA) transmission in the caudate putamen may be involved in food reward-related learning. The purpose of the present study was to evaluate the contribution of DA terminals in the dorsal caudate putamen to food-rewarded operant responding. Experiment 1, a study measuring circling behaviour in 18 rats receiving systemic amphetamine (1.5 mg/kg) and unilateral intracaudate putamen injections of cis-flupenthixol (0.0, 1.0, 10.0, and 25.0 micrograms in 0.5 microliters), a DA receptor antagonist, or its pharmacologically inactive isomer trans-flupenthixol (25.0 micrograms in 0.5 microliter), determined a behaviourally effective dose of cis-flupenthixol. Results showed that cis-flupenthixol dose dependently increased ipsiversive turning and trans-flupenthixol did not. In Experiment 2, an operant study, 36 rats were trained to press a lever for food on a variable interval 30-s schedule. Rats were then randomly assigned to four groups, three of which received one of the following bilateral intracaudate injections prior to three subsequent test sessions: saline (n = 6; 0.5 microliters), cis-flupenthixol (n = 10; 25.0 micrograms/0.5 microliter), and trans-flupenthixol (n = 10; 25.0 micrograms/0.5 microliters). Rats in the home cage control group (n = 10) received two bilateral intracaudate putamen injections of cis-flupenthixol (25.0 micrograms/0.5 microliters) in their home cages and a final injection of cis-flupenthixol prior to a test session. The results showed that cis-flupenthixol, but not trans-flupenthixol or saline, produced a time-dependent intrasession decline in operant responding. This pattern resembled that seen in extinction.(ABSTRACT TRUNCATED AT 250 WORDS)
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