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  • Title: [Combination induction of cell differentiation of HL-60 cells by daidzein (S86019) and BC-4 or Ara-C].
    Author: Jing YK, Han R.
    Journal: Yao Xue Xue Bao; 1993; 28(1):11-6. PubMed ID: 8328263.
    Abstract:
    Experiments demonstrated that the cell differentiation of HL-60 cells induced by low concentrations of daidzein (S86019), BC-4 (active principle of Boswellia carterii Birdw) and Ara-C was not impressive. However, when they were used in combination 80% of HL-60 cells exhibited NBT reduction and 82% of the cells showed phagocytosis after four days exposure to daidzein and BC-4. When HL-60 cells were exposed to daidzein and Ara-c, 70% of the cells exhibited NBT reduction and phagocytosis. Flow cytometry indicated that the majority of the cells were blocked at G1 phase under the induction of combination of daidzein with BC-4 or Ara-C.
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