These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Studies on the bioavailability and pharmacokinetics of nimodipine tablet in human body].
    Author: Yan XF, Ding DY, Liu RJ.
    Journal: Yao Xue Xue Bao; 1993; 28(1):45-9. PubMed ID: 8328270.
    Abstract:
    The article determined the bioavailability and pharmacokinetic parameters of two kinds of nimodipine tablets produced by Tianjin Center Pharmaceutical Factory in 6 healthy volunteers using HPLC method. The commercially available conventional tablet A and the tablet formulation B were compared with the reference solution C in vivo. The pharmacokinetic parameters of nimodipine in vivo were estimated by using PKBP--N1 program on the basis of one compartment open model. After administration of 120 mg dose of B, the pharmacokinetic parameters were as follows: Tp = 0.977 h, Cmax = 44.28 ng/ml, ka = 2.02 h-1, t1/2 = 1.63 h, Vd = 26.25 L/kg, AUC = 136.56 ng.h-1.ml-1. The result imply that nimodipine is absorbed rapidly, distributed widely in the body, and also eliminated at a fairly rapid rate. The bioavailability of A and B relative to C was 16.01% and 82.39% respectively. The new tablet formulation B is superior to tablet A.
    [Abstract] [Full Text] [Related] [New Search]