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  • Title: Biosynthesis of vasopressin by gastrointestinal cells of Brattleboro and Long-Evans rats.
    Author: Friedmann AS, Memoli VA, Yu XM, North WG.
    Journal: Peptides; 1993; 14(3):607-12. PubMed ID: 8332556.
    Abstract:
    The distribution of vasopressin, provasopressin, vasopressin-associated neurophysin, and vasopressin-associated glycopeptide was determined immunohistochemically in the gastrointestinal system of Brattleboro and Long-Evans rats. Cells containing immunoreactivity for vasopressin, provasopressin, neurophysin, and glycopeptide were detected in the same cell types of the stomach and duodenum, while selected cells in the duodenum contained only immunoreactive glycopeptide. Unlike that in the hypothalamus, staining for neurophysin in the gastrointestinal tract was sensitive to fixation. These findings indicate that vasopressin is produced by cells in the rat gastrointestinal system and suggest the existence of synthetic pathways different from those found in hypothalamic neurons.
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