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  • Title: [The effect of irradiation of the thymus, the hypothalamo-hypophyseal area and the gonads on the growth of a transplanted Lewis carcinoma in mice].
    Author: Savina NP, Iarilin AA, Konopliannikov AG.
    Journal: Radiobiologiia; 1993; 33(3):329-36. PubMed ID: 8332709.
    Abstract:
    Irradiation of thymus with doses of 0.5 to 10 Gy and gonads with 10 Gy does not influence the growth of the tumor transplanted 10 days after irradiation and accelerates the growth of the tumor transplanted 11-12 months after exposure. Irradiation of hypophysis and hypothalamus with doses of 1 and 10 Gy accelerates the growth of the tumor transplanted 10 days and 11-12 months after exposure. In the latter case the effect was more pronounced. When thymus, hypothalamus and hypophysis were exposed simultaneously the effect was analogous to that observed after isolated exposure of hypothalamus/hypophysis but somewhat more pronounced. Irradiation of hypothalamus/hypophysis caused earlier and severer changes in the anti-tumor resistance than the exposure of thymus and gonads did.
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