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  • Title: In vivo and in vitro effect of bacterial endotoxin on erythroid precursors (CFU-E and ERC) in the bone marrow of mice.
    Author: Udupa KB, Reissmann KR.
    Journal: J Lab Clin Med; 1977 Feb; 89(2):278-84. PubMed ID: 833466.
    Abstract:
    Erythropoietin injection raised within 24 hr. the number of CFU-E in the femoral marrow of polycythemic mice by 837 percent. Endotoxin given at 0 to 24 hr. before erythropoietin nearly abolished this CFU-E increase. Endotoxin in the culture medium did not inhibit erythroid colony formation, but in vivo endotoxin suppressed erythropoietin-induced differentiation of proerythroblasts from their precursors. Endotoxin thus suppresses marrow erythropoiesis either by inhibiting transformation of erythroid precursors into CFU-E or by causing the disappearance, perhaps by emigration, of CFU-E from the marrow.
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