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  • Title: Immunoelectron localization of HLA-DR, HLA-DP, and HLA-DQ antigens on the microvasculature in normal skin.
    Author: Suzumura Y, Ohashi M.
    Journal: J Am Acad Dermatol; 1993 Aug; 29(2 Pt 1):202-5. PubMed ID: 8335739.
    Abstract:
    BACKGROUND: Expression of HLA-DP and HLA-DQ antigens on the microvasculature in normal skin is uncertain. OBJECTIVE AND METHODS: We investigated expression of HLA-DR, HLA-DP, and HLA-DQ antigens on the microvasculature in normal skin by light and electron microscopic immunohistochemistry. RESULTS: HLA-DP and HLA-DQ antigens were expressed on the microvasculature, but the intensity of positiveness was variable. By immunoelectron microscopy, HLA-DR, HLA-DP, and HLA-DQ antigens were expressed on the endothelial cells of the microvasculature, but not on the pericytes and the smooth muscle cells. The luminal surface of endothelial cells had a stronger expression of these antigens than the abluminal surface. CONCLUSION: HLA-DR, HLA-DP, and HLA-DQ antigens are expressed on endothelial cells of the microvasculature in normal skin.
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