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  • Title: [Adrenal cortex function in children with bronchial asthma in fluticasone therapy].
    Author: Hoffmann-Streb A, L'Allemand D, Niggemann B, Büttner P, Wahn U.
    Journal: Monatsschr Kinderheilkd; 1993 Jun; 141(6):508-12. PubMed ID: 8336748.
    Abstract:
    In order to study the adverse reaction of a new, inhaled steroid (Fluticasone) on the pituitary-adrenocortical axis in asthmatic children, we investigated 7 children (aged 7 to 15 years) before and during treatment with Fluticason (100-200 micrograms/day). For the dosage tested, we found no depression of adrenal function, neither in circadian cortisol secretion nor in hCRH-stimulation-test. Another 7 asthmatic children under treatment with Budesonide (800 micrograms/day) were examined by the same tests. They equally did not show an adrenocortical suppression. However, in 4 other children under therapy with oral prednisone (2.5 to 7.5 mg/day), there was a marked suppression on adrenocortical function, even with low doses of the steroid. We conclude that Fluticasone (as well as Budesonide) in the above dosages represent a safe therapy for bronchial asthma in children.
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