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  • Title: [The character of the interaction of beta-carotene-15,15'-dioxygenase from rabbit small intestine with lycopene, 15,15'-dehydro-beta-carotene, lutein, and astaxanthine].
    Author: Ershov IuV, Dmitrovskiĭ AA, Bykhovskiĭ VIa.
    Journal: Biokhimiia; 1993 May; 58(5):733-9. PubMed ID: 8338885.
    Abstract:
    Interaction of rabbit small intestine mucosa beta-carotene 15,15'-dioxygenase with lycopene, 15,15'-dehydro-beta-carotene, lutein and astaxanthine is unaccompanied by the formation of products of enzymatic cleavage of the central double bond of these carotenoid molecules. Apo-carotenoids of lutein and lycopene are formed by nonenzymatic oxidation. Lycopene and 15,15'-dehydro-beta-carotene competitively inhibit the enzymatic oxidation of beta-carotene. Inhibition of the enzyme conversion by lutein and astaxanthin is less strong, being of a competitive-noncompetitive type. Enzymatic formation of retinal from beta-carotene depends on the accessibility of substrate molecules.
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