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  • Title: The effects of chronic prenatal exposure to nicotine on the behavior of guinea pigs (Cavia porcellus).
    Author: Johns JM, Walters PA, Zimmerman LI.
    Journal: J Gen Psychol; 1993 Jan; 120(1):49-63. PubMed ID: 8340785.
    Abstract:
    Three groups of 15 offspring from guinea pig dams were injected twice daily throughout gestation with one of three doses (0.5, 1.5 or 2.5 mg/kg) of nicotine-hydrogen tartrate. These offspring and 15 saline-exposed offspring were tested on several behavioral measures. Offspring of nicotine-treated dams had significantly lower rates of spontaneous alternation as neonates. The 1.5 and 2.5 mg/kg nicotine-exposed offspring also alternated less at puberty than control offspring and would not enter an unfamiliar stimulus alley that a majority of controls entered. Nicotine offspring, as adults, performed significantly poorer than their controls on errors and trials to criterion on a discrimination and reversal task. Prenatal nicotine treatment resulted in performance deficits on both learned and innate behavioral measures throughout development and adulthood.
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