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  • Title: Syntheses of 5'-substituted analogues of carbocyclic 3-deazaadenosine as potential antivirals.
    Author: Secrist JA, Comber RN, Gray RJ, Gilroy RB, Montgomery JA.
    Journal: J Med Chem; 1993 Jul 23; 36(15):2102-6. PubMed ID: 8340914.
    Abstract:
    Various 5'-substituted derivatives (2, 3, 6a, 6b, 9a, 9b, 12, 13b, and 15) of carbocyclic 3-deazaadenosine (3-deaza CAdo, 1) were prepared from 3-deaza CAdo (1) and evaluated as antiviral agents against a number of viruses, including HIV-1. Several of the compounds had moderate to good antiviral activity against vaccinia (VV) and vesicular stomatitis (VSV) viruses; however, the antiviral activity of the analogues did not exceed that of the parent compound. No anti-HIV activity was detected.
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