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  • Title: Specific effect of haloperidol on dopamine turnover in the frontal cortex.
    Author: Laduron P, de Bie K, Leysen J.
    Journal: Naunyn Schmiedebergs Arch Pharmacol; 1977 Jan; 296(2):183-5. PubMed ID: 834317.
    Abstract:
    A single injection of haloperidol (0.08 mg/kg) produced marked increases in HVA in rabbit brain. Of the dopamine-containing areas studied, the elevation of HVA was significantly greater in the frontal cortex than in the striatum, the tuberculum olfactorium or the parietal cortex. After chronic treatment, a tolerance phenomenon to the effects of haloperidol on HVA was observed only in the striatal and limbic areas. The present results suggest that the frontal cortex may be a preferential target for the antipsychotic activity of neuroleptic agents.
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