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  • Title: Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine.
    Author: Cheng X, Kumar S, Posfai J, Pflugrath JW, Roberts RJ.
    Journal: Cell; 1993 Jul 30; 74(2):299-307. PubMed ID: 8343957.
    Abstract:
    The first three-dimensional structure of a DNA methyltransferase is presented. The crystal structure of the DNA (cytosine-5)-methyltransferase, M.HhaI (recognition sequence: GCGC), complexed with S-adenosyl-L-methionine has been determined and refined at 2.5 A resolution. The core of the structure is dominated by sequence motifs conserved among all DNA (cytosine-5)-methyltransferases, and these are responsible for cofactor binding and methyltransferase function.
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