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  • Title: Prognostic significance of nucleolar organizer regions in ovarian epithelial tumors.
    Author: Criscuolo M, Martinelli AM, Migaldi M, Zunarelli E, Bergamaschi M, Falchi AM, De Gaetani C.
    Journal: Int J Gynecol Pathol; 1993 Jul; 12(3):259-63. PubMed ID: 8344763.
    Abstract:
    Recent studies have shown that the silver-stained nucleolar organizer region (AgNOR) score is related to the cell growth rate in several neoplasms. In the work presented here, we tested the AgNOR technique in 79 ovarian epithelial tumors (13 benign, 10 borderline, 56 malignant) to evaluate the diagnostic potential of AgNOR count in distinguishing between ovarian borderline tumors and carcinomas and to assess its prognostic value in carcinomas. Ovarian carcinomas exhibited higher mean AgNOR values than borderline and benign tumors, but statistically significant differences were found only in the serous type. Statistical analysis showed a positive correlation of higher AgNOR score, advanced tumor stage, and adverse prognosis. On the contrary, low AgNOR counts identified stages I and II carcinomas with disease-free follow-up. These results suggest that the AgNOR count may improve the prognostic evaluation of ovarian epithelial tumors by representing a reliable indicator of survival.
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