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  • Title: Tissue-type plasminogen activator (t-PA) lysis of aortic and mitral valve thrombosis.
    Author: Sugano T, Fujiwara H, Adachi S, Sugimoto K, Amano J, Suzuki A.
    Journal: J Cardiovasc Surg (Torino); 1993 Jun; 34(3):259-61. PubMed ID: 8344979.
    Abstract:
    Valve thrombosis is one of the most serious complications after prosthetic valve replacement. We report the use of tissue-type plasminogen activator (t-PA) in the treatment of a patient with thrombosed aortic and mitral valves. Thrombolysis resulted in immediate hemodynamic improvement and resolution of congestive heart failure, thereby avoiding surgical intervention. Based on our experience, thrombolysis with t-PA is an effective alternative in the treatment of thrombosed prosthetic valves.
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