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  • Title: Male pseudohermaphroditism with partial androgen insensitivity.
    Author: Keenan BS, Kirkland JL, Kirkland RT, Clayton GW.
    Journal: Pediatrics; 1977 Feb; 59(2):224-31. PubMed ID: 834506.
    Abstract:
    Androgen insensitivity was demonstrated in two male siblings with partial masculinization of the external genitalia. They had a previously undescribed defect characterized postpubertally by high plasma testosterone and luteinizing hormone concentrations with low serum follicle-stimulating hormone levels. Studies in skin fibroblasts showed normal androgen receptor affinity and capacity for 5alpha-dihydrotestosterone (DHT), normal nuclear retention of the receptor-DHT complex, and normal conversion of testosterone to DHT.
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