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  • Title: [Elevation of serum apo E-rich HDL concentration in a patient with cholestatic liver disease].
    Author: Umemori Y, Chiba H, Moriyama T, Takeda S, Hosokawa H, Nobuoka M, Makino M, Eto M, Akiyama K.
    Journal: Rinsho Byori; 1993 Mar; 41(3):307-12. PubMed ID: 8345664.
    Abstract:
    A remarkable elevation of serum HDL cholesterol concentration (165mg/dl) was found in a 42-year-old Japanese male with chronic pancreatitis who had been cholestatic for several years. An abnormal slow alpha-migrating lipoprotein, larger in particle size and more enriched with cholesteryl ester and apo E than normal HDL, was found in the patient's plasma. Quantitative determination of apo E-rich HDL revealed a striking increase of this lipoprotein in plasma. After choledocho-jejunostomy, a prompt and remarkable decrease of plasma apo E-rich HDL was observed, indicating a direct contribution of cholestasis to the accumulation of apo E-rich HDL in plasma in this patient.
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