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  • Title: [Successful oral administration of etoposide therapy for refractory malignant lymphoma treated with frequent combination chemotherapy].
    Author: Ayabe T, Maekawa I, Ashida T, Taruishi M, Shibata Y, Namiki M.
    Journal: Gan To Kagaku Ryoho; 1993 Aug; 20(10):1391-5. PubMed ID: 8346939.
    Abstract:
    A 67-year-old man was diagnosed as non-Hodgkin lymphoma (diffuse, mixed cell type, B cell) with clinical stage IV in March 1989. He had been treated many times with salvage chemotherapy on admission including CHOP-etoposide and ProMACE-Cyta BOM. Recurrence, however, occurred in two or three months after any therapy. He had a therapeutic history of chronic daily administration of etoposide. In November 1991, recurrence was found in the peripheral lymph node and the colon. A new regimen of oral administration of etoposide, 50 mg/day four times a week, was employed. Two months later, the peripheral lymph node swelling disappeared. Seven months later, the patient showed no signs of recurrence by Ga-scintigraphy. This therapy is being continued. It is suggested that anti-neoplastic activity of etoposide is dependent on the schedule of administration. This regimen is suggested to be effective in the treatment of patients with refractory malignant lymphoma.
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