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  • Title: Absence of an association between HLA-DRB1*04 and rheumatoid arthritis in newly diagnosed cases from the community.
    Author: Thomson W, Pepper L, Payton A, Carthy D, Scott D, Ollier W, Silman A, Symmons D.
    Journal: Ann Rheum Dis; 1993 Jul; 52(7):539-41. PubMed ID: 8346982.
    Abstract:
    OBJECTIVES: To determine HLA-DR4 and DR1 allele frequencies in a series of patients with newly diagnosed early inflammatory arthritis. METHODS: HLA-DR1 and DR4 frequencies were determined by oligonucleotide typing of 208 patients classified as having either rheumatoid arthritis (RA) or undifferentiated inflammatory polyarthritis. RESULTS: The frequency of occurrence of DR4 in these patients with RA did not differ significantly from that in controls in the United Kingdom (42 v 37%). HLA-DR1 was increased in the group with inflammatory polyarthritis (25 v 18%). CONCLUSIONS: The frequency of DR4 is not increased in newly diagnosed community based patients with RA. This supports the hypothesis that DR4 is less important as a marker for susceptibility to RA than it is for disease persistence or severity.
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