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  • Title: [The new antidepressant tetrindole].
    Author: Mashkovskiĭ MD, Glushkov RG, Shvedov VI, Andreeva NI, Golovina SM.
    Journal: Eksp Klin Farmakol; 1993; 56(2):3-6. PubMed ID: 8348033.
    Abstract:
    The antidepressive effects of tetrindole versus pyrazidole (pirlindole) and imipramine were studied in animal experiments. Tetrindole was found to be more active than pyrazidole and imipramine in a behavioral model of Porsolt, in antagonism with reserpine, in potentiation with 5-hydroxytryptophan, L-dopa and clonidine. The action of terindole is related to its ability to exert reversible inhibitory effects on MAO A activity. Tetrindole is less toxic than pyrazidole and imipramine.
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