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  • Title: TRP-1 expression correlates with eumelanogenesis in human pigment cells in culture.
    Author: del Marmol V, Ito S, Jackson I, Vachtenheim J, Berr P, Ghanem G, Morandini R, Wakamatsu K, Huez G.
    Journal: FEBS Lett; 1993 Aug 02; 327(3):307-10. PubMed ID: 8348959.
    Abstract:
    We have investigated the relationship in human cultured normal and malignant melanocytes between the accumulation of mRNAs encoding tyrosinase and tyrosinase-related protein-1 (TRP-1), the activity of tyrosinase and the presence of melanin. Tyrosinase mRNA correlates with tyrosinase activity and with the presence of pheomelanin, eumelanin or both melanin types. In contrast TRP-1 mRNA is only detectable in cells containing eumelanin, which suggests a role for TRP-1 in the eumelanin synthesis pathway.
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