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  • Title: Activation of neutrophils NADPH oxidase by PMA: cytosol activity is translocated in phorbol-primed neutrophils.
    Author: Umei T, Ohhara N, Okamura S, Harada M, Nakao M, Shirai T, Niho Y.
    Journal: Int J Biochem; 1993 May; 25(5):631-3. PubMed ID: 8349005.
    Abstract:
    1. Translocation of cytosol activity in phorbol-primed neutrophils was studied. 2. Prior exposure of PMA or FMLP could potentiate the oxidative response by subsequent heterogeneous stimulus, FMLP or PMA. 3. In FMLP-primed neutrophils, the cytosol had almost the same activity as resting one and cytosol activity was not eluted from the membrane. 4. In PMA-primed neutrophils, however, the cytosol had less activity and cytosol activity was correspondingly eluted from the membrane. 5. These observations suggested that cytosol activity was translocated in PMA-primed cells.
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