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  • Title: Anti-Mlsa-like effect of CBA/J anti DBA2 antibody in in vitro MLRs between Mls incompatible combinations.
    Author: De Giorgi L, De Matos C, Matossian-Rogers A.
    Journal: Immunol Lett; 1993 May; 36(2):171-8. PubMed ID: 8349313.
    Abstract:
    Antisera from CBA/J (H-2k,Mlsa) mice hyperimmunised with DBA2 (H-2d,Mlsa) and/or AKR (H-2k,Mlsa) splenocytes, can block in vitro MLRs against Mlsa determinants. These two antisera are furthermore specifically cytotoxic against targets expressing H-2 components but not against Mlsa-bearing targets. In these experimental models the anti-Mlsa-like effects of CBA/J anti-DBA2 and CBA/J anti AKR antibodies seem to be associated with an autoreactive immune response in CBA/J mice elicited by DBA2 and AKR splenocytes, respectively. In this report we propose that anti-Mlsa antibodies can also be generated in a situation in which Mlsa is presented as 'altered self' in conjunction with allo-determinants.
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