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  • Title: Higher relative risk of spondyloarthropathies among B27 positive Indonesian Chinese than native Indonesians.
    Author: Nasution AR, Mardjuadi A, Suryadhana NG, Daud R, Muslichan S.
    Journal: J Rheumatol; 1993 Jun; 20(6):988-90. PubMed ID: 8350336.
    Abstract:
    We assessed the prevalence of HLA-B27 among ethnic Indonesian and Indonesian Chinese patients with ankylosing spondylitis (AS) or related spondyloarthropathies, and also among healthy controls. HLA-B27 was found in 23 (62.2%) of 37 Chinese patients and 4% of 176 Chinese healthy controls (p < 0.001). In contrasts only 2 (8.3%) of 24 native Indonesian patients and 13 (9%) of 145 healthy controls were HLA-B27+, indicating the lack of association of HLA-B27 with spondyloarthropathies in native Indonesians. These findings also suggest that HLA-B27 Chinese Indonesians carry a greater relative risk of developing AS and related spondyloarthropathies than native Indonesians, although the prevalence of HLA-B27 in the general population is more than 2 times higher in native Indonesians.
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